Archive for the ‘Uncategorized’ Category

The FDA expands the availability of generic Doxycycline

Tuesday, September 23rd, 2008

Doxycycline is one of the tetracycline antibiotics that was developed during the 1960s by Pfizer Inc. No matter what the status of a drug as patented or not, it’s for the FDA to regulate all manufacturing for distribution within the U.S. The good news for consumers is that this August has seen the FDA license the Lannett Company Inc. to produce the whole range of Doxycycline tablets from 50mg through 150mg. That means if you are unlucky and contract one of the infections caused by a susceptible bacterium, you have a cheap cure available. So if you’re down with pneumonia, a respiratory or urinary tract infection, one of the sexually transmitted diseases or something less common, reach for cheap Doxycycline. It received its FDA approval in 1967. Being a little long in the tooth, it has passed out of patent protection so there are now generic versions on the market. This is great for patients as consumers because the competition between Pfizer and the new manufacturers has brought the price tumbling down. This newly licensed company is a specialist generic manufacturer and its appointment really improves the supply of this important antibiotic across all U.S. states. If you can’t find it in your local pharmacy, you guarantee to buy Doxycycline online.

Is it a social conscience or self-interest that should motivate us?

Saturday, September 20th, 2008

It is charming to browse around the internet. There is always somebody thinking something interesting somewhere in the world. All you have to do is to find him or her. E.g. take one history in California. It raises the difficult question of how you should dispose of “pills” you no longer need or which have expired. You could, of course, get in your car and drive down to your local pharmacy. But, the majority of us probably find the effort involved a deterrent. Why go to so much effort when you have a dumpster just outside your door? Or, if even that is too much effort, there is always the option to flush the problem away. Who would know? Who cares anyway?
In fact, Ambien works in exactly the same way as a conventional benzodiazepine and is probably just as addictive. For this reason, Ambien is listed by the Drug Enforcement Agency (DEA) as a controlled substance in Schedule IV. You will be pleased and delighted to know that the US Government has your interests at heart. It always wants to protect you and the environment (”always” is probably a slight exaggeration). State and Federal regulations limit the handling and disposal of controlled substances to DEA-authorised individuals and organisations. The DEA’s Office of Diversion Control aims to prevent the diversion of legitimately manufactured (or used) controlled substances into the illegal drug traffic. If there is no-one else immediately available to handle the disposal, the controlled substances should be collected by a law enforcement officer. So, if your local pharmacy has not registered with the DEA, their only way of disposing of your unwanted drugs is to call the cops. No wonder they looked so pleased when you asked. But San Mateo County, California has placed collection boxes inside the entrance halls of eleven police departments. Anyone can walk in and leave their unwanted medications (including Ambien but excluding all illegal substances) and walk out - no questions asked. And is this a welcome service? Over the first fifteen months of the program, local citizens have deposited 1,800 pounds of medications (not all Ambien, of course). So there is clearly a demand for this kind of service. It is pure self-interest, of course. Who wants to get high from drinking tap water? Hmmm. Wait, that is not quite the right question. I don’t know many men who would argee to take female hormones. And do we really want all those bacteria out there to get used to all those antibiotics in the water? If you don’t know the answers to these and other questions of social conscience, take an Ambien and sleep on it.
Do you ever wonder what happens after casual disposal? Your local waste management authority comes round to collect the refuse which is then dumped. There is little or no effort to sort the waste. Most authorities simply drive to the nearest landfill site and tip each load on to the growing mound of other rubbish. This pile then rots down as rain washes through it so, sooner or later, dissolved drugs end up in the watertable and potentially get recycled into your drinking water. The medications flushed go more directly into the water supply. So here is the worry. The rivers downstream from you supply water to the local towns and cities. That water supply contains what the experts call a “sub-lethal” cocktail of antibiotics, sedatives, painkillers, hormones and whatever else you so casually threw away. Perhaps you have no interest in the people downstream of you. I wonder what the people upstream think of you. But, back to Ambien. Ambien is, of course, a nonbenzodiazepine hypnotic. I am never reassured by the prefix “non”.

Xanax is the most popular benzodiazepine in the US

Tuesday, September 9th, 2008

Every year, Xanax has been winning the prize in the “bestseller” category. Naturally, Pfizer, the manufacturer, loves these annual headlines. If you take xanax for the right reasons and under proper medical supervision, it does reduce levels of panic and anxiety. The US Government now accepts that prescription medications are routinely abused. You only have to go into the emergency departments of hospitals to see the truth of this. But you can’t change the fact that it’s one of the benzodiazepines. That means it’s habit-forming. Take it for too long or at too high a dose and you’re likely to get hooked. So before you go down this path, think carefully. In 2005, there were more than 2 million admissions caused by the non-medical use of drugs. One of the reasons for this is the easy availability of drugs that can give you a “high” both over-the-counter and through the internet. Add in the continuous barrage of advertisements for drugs, and people are persuaded to take FDA-approved medications without worrying about the consequences. The way the world works today, people do need help. Xanax-like drugs really help them to cope with the stress. But it’s not helpful to see drugs as the only solution. Yes, xanax relieves anxiety, but you don’t want to become an addict. You need to change yourself. This drug gives you a breathing space. In the medium to long term, psychological support is the way to learn how to control your fear and worry. Live life the natural way, don’t pay endlessly for “help” through a bottle of tablets.

Olympics. Win gold with Cialis!

Friday, September 5th, 2008

One of the world’s leading scientists specialising in sports drugs, has gone on the record. It’s official. He’s discovered several interesting side-effects of some existing and well-known drugs. Perhaps some of the better informed athletes have been using these techniques at the Olympics at Beijing. If so, we’ll never know. Well, let’s start with the go-faster tattoos. I love these ideas. Researchers at the Deutsches Krebsforschungszentrum - the cancer research center in Germany - have shown that tattooing is sixteen times more effective than injections in delivering a drug into the body. So, you get the same effect with one-sixteenth of the dose and that makes the dose so much harder to detect. But the most interesting ideas are the use of Cialis and nitrous oxide gas. Yes, friends, inhaling laughing gas makes you go faster, jump higher, and so on. The point is that both operate as vascular dilators - they open up your blood vessels. Blood flows increase and bring more oxygen to those working muscles faster. The advantage of Cialis or Levitra is that it stays in the body for longer - it’s not called the “weekend” pill. So the next time you see a runner coming down the street towards you covered in tattoos, popping pills and breathing from a gas canister, you see next Olympian in training.

Women, wine and smoke

Wednesday, September 3rd, 2008

We all have to learn where our limits are. Of course, this includes sex and most will experiment both with conventional sex and sex in conjunction with recreational drugs. Taking cialis to maintain stamina over a long weekend of activity is safe. Other substances may be less helpful. Then, as we grow older, the body can start presenting us with the bills for our past excesses. Clinical studies have now established that about a quarter of all cases of erectile dysfunction are caused by smoking and/or substance abuse. Put another way, male smokers who have high blood pressure are 26 times more likely to suffer ED. Former smokers with high blood pressure are 11 times more likely to suffer ED than those who have never smoked. Smoking also accelerates arteriosclerosis and this can reduce the flow of blood into the penis. The combination of diabetes and smoking not only encourages ED but also increases the risk of strokes and heart attacks. Why does this happen? The problem is the inhaled carbon monoxide. It combines with the haemoglobin in the red blood cells and limits the capacity of the cells to carry oxygen around the circulatory system. The lack of oxygen leads to a hardening of the artery walls and a reduction in the amount of blood that reaches the peripheral extremities of the body (including the penis and testicles). Worse, it also contributes to a general loss of libido and a reduction in the sperm count. We all probably enjoy a little drink of alcohol from time to time. It tends to make social events go more smoothly. Unfortunately, the more we drink the greater the potential damage to the blood vessels. Alcohol increases blood pressure. In the short term, sexual performance may improve because we are less inhibited (no performance anxiety) but, if this should tip into excess and alcoholism, ED usually results. The best answer is always prevention. Never smoking, whether actively or passively, preserves our health. Similarly, never drinking excessively and then only drinking a little red wine every day, reduces the risks of heart disease. If we started to smoke, stopping immediately is the ideal. If there are signs of ED, taking cialis pills will probably be sufficient to restore full function. But if the damage is too great, then further medications may be required. Should you have reached the tipping point into alcoholism and a loss of libido, there are programs that help you to quit the alcohol, and there is always cialis to try to restore you interest in sex.

What is he thinking?

Friday, August 29th, 2008

For once, I’m going to put on my physician’s hat and give you the view from the other side.

Well, my first step was to review the medical records to see if there were any immediate clues. If there are existing diseases or one of the medications currently on prescription has an ED side effect, we have solved the case before we start. I should let you in on a small medical secret. About a quarter of all the cases that we see are drug-related. Usually, we simply change the medication and the ED goes away. Alternatively, we have to counsel lifestyle changes because the excessive alcohol consumption or recreational drug of choice is not doing the patient any favors.

So my patient has walked through the door and, in the same breath as blurting out that he’s suffering erectile dysfunction (ED), he’s also into the knee-jerk questions about where to buy Viagra, should he risk buying Viagra online, and so on. I know Pfizer Inc. did a wonderful thing when they invented Viagra, but that medication so dominates the public consciousness that many men seem have never even heard about Cialis and Levitra, let alone all the other treatments that are available and may be necessary. Still even though my patients are predictable, they are at least coming through the door to get treatment. Ten years ago that did not happen. The world is a better place thanks to Pfizer Inc. The next most obvious possibility is Diabetes. I may also do a blood sugar test just to be thorough. Blood pressure tests out in the normal range, so that’s another good sign.

The questions are designed to establish whether we’re dealing with problems of desire (which could be psychological or physical), whether it’s purely ED or there are also problems with achieving orgasm, and to check up on those lifestyle choices which could be the real problem.

The physical examination tries to cover as many possibilities as possible in as short a time as possible. Most men find an examination deeply embarrassing so keeping it short is a “good thing”. I’m looking for anything that might suggest a systemic problem. So, I’m obviously going to start with the penis. Some of my questions have probed whether the penis has changed shape in any way or perhaps the erection is painful. A physical examination could find evidence of lumps or the answers to the questions may reveal that the penis now bends or curves when erect, all of which could suggest Peyronie’s disease. Similarly, if the penis is not sensitive when I touch it, this may indicate possible problems in the peripheral nervous system.

Following the same idea and taking a quick overview of the body also allows me to look for any changes to the usual distribution of body hair or any enlargement to the pectorals (a polite way of suggesting that my patient may be developing small breasts). If the testicles feel slightly smaller than I would expect, this can suggest a low testosterone level. Any such abnormality can indicate problems with the hormone balance or the endocrine system. I’m also testing the pulses in both the wrists and ankles. If there are any circulatory problems, I’m likely to find a decrease pulse at the extremities.

So these are all the quick and easy explanations. In most cases, there is little to suggest the need to go on to further tests and I can then get into a discussion of the medication options. This is when the patient finally begins to look more comfortable again. We have finally come back to his original questions, except that I’m also telling him about Cialis and Levitra. Viagra may have the name, but Cialis in particular does have some interesting characteristics.

What about cannabis?

Wednesday, August 27th, 2008

On July, the Federation of European Pharmacological Societies Congress discussed the medicinal role of cannabis. It is routinely used for controlling nausea among patients on chemotherapy and for encouraging appetite among AIDS patients. Science is now developing medications that focus on the parts of the body affected by disease and not the central nervous system. So, for example, when the body is injured cannabinoids are naturally released in the affected area and reduce pain. Unfortunately, the effect is very short-lived. Thus, research is now aiming to produce more medications that maintain cannabinoid levels in the affected areas for pain relief and for the control of anxiety and depression. The converse treatments are also working well for dealing with nicotine addiction and obesity. The main problem with cannabis is in its addictive nature. So, medications like acomplia that block the cannabinoid receptors help to reduce addictive behavior and reduce appetite. Acomplia is now a front line treatment for obesity in Europe, second in effectiveness only to the use of gastric bands or surgical bypasses (which reduce weight by an average of 30%). By coincidence, the French health authority Afssaps also released new statistics confirming the safety profile of acomplia in relation to depression. People with no history of depression show no adverse symptoms. Others only show an increase in depression at the beginning of a course of treatment. This can easily be monitored and compensated for.

The July conference heard news that one constituent of cannabis, THVC, may offer a better way to reduce appetite than acomplia and, more importantly, may be effective to treat neurodegenerative disorders like Huntington’s disease, Parkinson’s and Alzheimer’s. Why is more not heard about these advances? Possibly because of the prejudice that cannabis is a drug that should be banned. It is a shame society cannot see beyond a name to the good results science can produce.

When the cap fits.

Friday, August 22nd, 2008

I think I’m coming to Diabetes slightly later than I should. ED is a common early symptom of Type 2 Diabetes and cardiovascular disease. If you check through the literature, you’ll find that about 12% of patients who are later confirmed as diabetic first appear in the consulting rooms complaining of ED. Putting the cart before the horse, the evidence is that treating ED in cardiovascular patients who are also diabetic significantly reduces the mortality rate. So some good can come out of treating ED, usually with Viagra, Cialis or Levitra although, given that these drugs may not always be allowed as treatment, it is better to prevent the onset of the Diabetes if at all possible, say, by reducing excess weight.

A few years back, the Massachusetts Male Aging Study (MMAS) of men aged between forty and seventy years found that 28% of men with diabetes had ED - about three times the incidence in the general population. Averaging out the later surveys over the age range, ED develops between ten and fifteen years earlier in men with diabetes. Above the age of 50 years, between 50-60% of men with diabetes will have difficulties with an erection. Above 70 years, it is almost certain that diabetic men will have some difficulty with erectile function.

The cause of ED in diabetic men usually has organic elements. Even if the first cause is not psychological, the onset of organic ED almost inevitably produces serious performance anxiety and, if not treated, depression. The combination inevitably affects the libido and this reinforces the disability.

Decreased flow of blood into the penis through arterial narrowing, hardening and closure, high blood pressure, peripheral nerve damage, hormonal problems, say, because of decreased gonadal function, and obesity are all more common in diabetic men and each one may be the cause of your ED.

So that leaves us with the question of how we treat both the ED and the diabetes.

  • Good control over the level of blood sugar can prevent the nerve and blood vessel damage that leads to ED.
  • Smoking constrict and may block your blood vessels; and can also reduce nitric oxide levels, both of which which may limit the flow of blood into your penis.
  • Performance anxiety and depression can cause ED. To keep your stress levels under control, you should review your current tasks, and set more reasonable goals and deadlines.
  • Regular physical exercise can keep your arteries clear and boost your stamina. If you lack motivation, do not stay solitary. Join a club or gym.

Thus, there are well-established systems for treating both diabetes and ED. There is no need to suffer in silence. Your sex life can be restored in most cases, albeit that sometimes, you cannot rely on a simple pill to solve the problems.

As your physician, I can also consider Viagra, Cialis or Levitra, but these drugs are not safe if you are taking nitrates to treat heart disease or alpha blockers to treat high blood pressure or prostate enlargement This takes us into new territory for these articles. The vacuum constriction device works no matter what the cause of the ED. If you find the idea of using this piece of equipment off-putting, there is the possibility of intracavernosal injections to the penis to help stimulate an erection. Surgery and penile prostheses implantation are highly successful, but there are greater risks of infection when operating on diabetic men.

Which is more important? The plumbing or emotions?

Wednesday, August 20th, 2008

All contemprorary medical books have become much more informative recently. A simple statement reflecting the vast amount of knowledge that has been accumulated through research over the last one hundred years. Yet, when you look at these books, you are confronted by mountains of facts about increasingly minute processes within the body. Instead of simple engineering analogies of muscles and cables, human knowledge has become obsessed by the identification of ever more complex chemical and molecular processes. This is my wood-for-the-trees moment.

Nowadays ED is studied in details, depicted with wonderfull pictures and described in very interesting articles. However, it is not a part of the medical books to observe and describe the entirely human context in which the erection is supposed to operate. A single male may masturbate. A heterosexual couple may engage in sexual intercourse. A homosexual couple may offer mutual manual satisfaction, oral or anal intercourse. Multiple partners may engage in group sex. Many different social taboos would potentially be breached in any more detailed explanation. The common denominators are that the party or parties are expressing their sexuality in the ways that give them the most pleasure. The greater the pleasure we try to obtain the greater disappointment we gain in the end when we don’t obtain the result we want.

Will medical treatment be asked for and a success?

In part, this will be determined by the nature of the relationship. Where the relationship is socially disapproved, the man may well not seek treatment at all because of fear.If the parties to the relationship have a strong mutual commitment and lovingly support each other, the likelihood is that the co-operation between all involved would produce excellent medical outcomes. Well-established sexual intimacy and commitment preserve the right level of desire and motivate everyone to getting a solution that works well. Were it not for online pharmacies and their willingness to supply medications like cialis without prescription, many partnerships might never be able to get appropriate treatment of any kind.

Unfortunately, many pairs don’t get any treatment from the underlying causes of the ED. Although most will know that the dysfunction can be a symptom of diabetes and cardiovascular diseases, fear of exposure may force the couples or groups to ignore or deny the problem until it is too late for the easy treatment represented by cialis to continue on its own. By then, the chances of an effective treatment for the underlying cause may be remote.

This is two completely different cultural imperatives in conflict. Men are sure that one thing they must have everyday is erection. Any publicly acknowledged failure means shame. Yet they are only allowed to have erections in certain very carefully defined social situations. Step outside those situations and you are into potentially disapproved or even criminal territory. In theory, doctors are bound by duties of confidentiality, but the fear of exposure means that many men and their partners do not get treatment when the research shows that couples who are in love and share a strong commitment to their relationship are the ones who would most benefit from that treatment.